The major goal of the Pukkila-Worley laboratory is to characterize mechanisms of immune homeostasis in intestinal epithelial cells. We aim to further our understanding of inflammatory disorders in the intestine and use these discoveries to identify innate immune pathways that can be exploited to develop new therapies, which can modulate host immune activity. 

There are opportunities in our lab for post docs.

 Discretion 2

Exciting news from the Pukkila-Worley Lab:

  • 4/5/19: Nick was awarded a career development award from IDSA ()! 
  • 1/22/19: Our paper on nuclear hormone receptor-mediated immune activation was published in PLOS Genetics. 
  • 12/19/18: Elizabeth got into med school!
  • 10/1/18: Pleased that our grant from the Rainin Foundation was competitively renewed ()
  • 8/9/18: Kyle, Sarah and Nick all got spots on institutional training grants!
  • 7/1/18: Kyle Foster won a Poster Award at 2018 SPAMS C. elegans Meeting!
  • 5/1/18: Check out Nick's review in  
  • 4/15/18: Sarah and Nick passed their qualifying exams!
  • 8/24/17: Awarded an Innovator Award from the Ranin Foundation to fund our IBD work (, UMass announcent)
  • 8/3/17: A nice write-up about our work on UMassMed Now (link)
  • 7/27/17: Kyle got a spot on our institutional T32 training grant
  • 6/21/17: Our R01 was funded by NIH/NIAID
  • 5/8/17: Congrats to Kyle for passing his Qualifying Exam
  • 4/2/17: Congrats to Nick for rocking Step I of the USMLE
  • 9/28/16: A review from our lab in PLOS Pathogens (pdf)
  • 3/1/16: Our paper was published in G3: Genes, Genomes and Genetics ().
  • 11/17/16: Excited to receive a grant from the Charles H. Hood Foundation (press release).